[HTML][HTML] An induced proximity model for caspase-8 activation
The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs
in a hierarchical manner; the death domain of CD-95 binds to the corresponding domain in
the adapter molecule Fas-associated death domain (FADD) Mort-1, which in turn recruits the
zymogen form of the death protease caspase-8 (FLICE/Mach-1) by a homophilic interaction
involving the death effector domains. Immediately after recruitment, the single polypeptide
FLICE zymogen is proteolytically processed to the active dimeric species composed of large …
in a hierarchical manner; the death domain of CD-95 binds to the corresponding domain in
the adapter molecule Fas-associated death domain (FADD) Mort-1, which in turn recruits the
zymogen form of the death protease caspase-8 (FLICE/Mach-1) by a homophilic interaction
involving the death effector domains. Immediately after recruitment, the single polypeptide
FLICE zymogen is proteolytically processed to the active dimeric species composed of large …