Regulation of in vivo TSH secretion by leptin

LM Seoane, E Carro, S Tovar, FF Casanueva… - Regulatory peptides, 2000 - Elsevier
Leptin, the product of the ob gene, is a hormone secreted by adipocytes that regulates food
intake and energy expenditure. The hypothalamus–pituitary–thyroid axis is markedly
influenced by the metabolic status, being suppressed during food deprivation. The aim of the
present study was to assess whether leptin can act as a metabolic signal connecting the
adipose tissue with the pituitary–thyroid axis. We studied the effect of leptin administration
(10 μg, icv) on spontaneous TSH secretion and TSH responses to TRH in euthyroid and …