Angiogenesis, or formation of new blood vessels from pre-existing ones, is essential for
normal development and wound healing/reproductive functions in adults. Abnormal
regulation of angiogenesis has been implicated in the pathogenesis of several disorders,
including cancer. Vascular endothelial growth factor (VEGF)-A is a pivotal stimulator of
angiogenesis because its binding to VEGF receptors has been shown to promote
endothelial cell migration and proliferation, two key features required for the development of …