Val64Ile polymorphism in the CC chemokine receptor 2 is associated with reduced coronary artery calcification
AM Valdes, ML Wolfe, EJ O'Brien… - … , and vascular biology, 2002 - Am Heart Assoc
Arteriosclerosis, thrombosis, and vascular biology, 2002•Am Heart Assoc
Objective—Studies in mice have shown that genetic disruption of monocyte chemotactic
protein-1 or its receptor, the CC chemokine receptor 2 (CCR2), inhibits atherosclerosis, but
few data exist in humans to suggest that the monocyte chemotactic protein-1—CCR2
interaction is important in atherogenesis. A common polymorphism in the human CCR2
gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with
other disease phenotypes in humans. Methods and Results—A cohort of first-degree …
protein-1 or its receptor, the CC chemokine receptor 2 (CCR2), inhibits atherosclerosis, but
few data exist in humans to suggest that the monocyte chemotactic protein-1—CCR2
interaction is important in atherogenesis. A common polymorphism in the human CCR2
gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with
other disease phenotypes in humans. Methods and Results—A cohort of first-degree …
Objective— Studies in mice have shown that genetic disruption of monocyte chemotactic protein-1 or its receptor, the C-C chemokine receptor 2 (CCR2), inhibits atherosclerosis, but few data exist in humans to suggest that the monocyte chemotactic protein-1—CCR2 interaction is important in atherogenesis. A common polymorphism in the human CCR2 gene resulting in a substitution of isoleucine for valine (Val64Ile) has been associated with other disease phenotypes in humans.
Methods and Results— A cohort of first-degree relatives of persons with premature coronary artery disease was recruited and quantitatively phenotyped for the extent of CAC, a marker of coronary atherosclerosis, by using electron beam CT. The extent of CAC was significantly lower in subjects with the CCR2-Ile64 variant (Val/Ile and Ile/Ile genotypes) than in subjects carrying 2 Val64 alleles, even after adjustment for traditional risk factors.
Conclusions— This study provides genetic evidence linking CCR2 with coronary atherosclerosis in humans.
Am Heart Assoc