[HTML][HTML] STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-κB ligand and stimulation of osteoclastogenesis by gp130 …
CA O'Brien, I Gubrij, SC Lin, RL Saylors… - Journal of Biological …, 1999 - ASBMB
Interleukin (IL)-6-type cytokines stimulate osteoclastogenesis by activating gp130 in
stromal/osteoblastic cells and may mediate some of the osteoclastogenic effects of other
cytokines and hormones. To determine whether STAT3 is a downstream effector of gp130 in
the osteoclast support function of stromal/osteoblastic cells and whether the gp130/STAT3
pathway is utilized by other osteoclastogenic agents, we conditionally expressed dominant
negative (dn)-STAT3 or dn-gp130 in a stromal/osteoblastic cell line (UAMS-32) that supports …
stromal/osteoblastic cells and may mediate some of the osteoclastogenic effects of other
cytokines and hormones. To determine whether STAT3 is a downstream effector of gp130 in
the osteoclast support function of stromal/osteoblastic cells and whether the gp130/STAT3
pathway is utilized by other osteoclastogenic agents, we conditionally expressed dominant
negative (dn)-STAT3 or dn-gp130 in a stromal/osteoblastic cell line (UAMS-32) that supports …