[HTML][HTML] p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin iiinduced hypertrophy in vascular …
M Ushio-Fukai, AM Zafari, T Fukui, N Ishizaka… - Journal of Biological …, 1996 - ASBMB
Superoxide anion formation is vital to the microbicidal activity of phagocytes. Recently,
however, there is accumulating evidence that it is also involved in cell growth in vascular
smooth muscle cells (VSMCs). We have shown that the hypertrophic agent angiotensin II
stimulates superoxide production by activating the membrane-bound NADH/NADPH
oxidase and that inhibition of this oxidase attenuates vascular hypertrophy. However, the
molecular identity of this oxidase in VSMCs is unknown. We have recently cloned the …
however, there is accumulating evidence that it is also involved in cell growth in vascular
smooth muscle cells (VSMCs). We have shown that the hypertrophic agent angiotensin II
stimulates superoxide production by activating the membrane-bound NADH/NADPH
oxidase and that inhibition of this oxidase attenuates vascular hypertrophy. However, the
molecular identity of this oxidase in VSMCs is unknown. We have recently cloned the …