Calcium ionophore enables soluble agonists to stimulate macrophage 5-lipoxygenase.
CS Tripp, M Mahoney, P Needleman - Journal of Biological Chemistry, 1985 - ASBMB
The regulation of arachidonic acid conversion by the 5-lipoxygenase and the
cyclooxygenase pathways in mouse peritoneal macrophages has been studied using
particulate and soluble agonists. Particulate agonists, zymosan and latex, stimulated the
production of cyclooxygenase metabolites as well as the 5-lipoxygenase product,
leukotriene C4. In contrast, incubation with the soluble agonist phorbol myristate acetate or
exogenous arachidonic acid led to the production of cyclooxygenase metabolites but not …
cyclooxygenase pathways in mouse peritoneal macrophages has been studied using
particulate and soluble agonists. Particulate agonists, zymosan and latex, stimulated the
production of cyclooxygenase metabolites as well as the 5-lipoxygenase product,
leukotriene C4. In contrast, incubation with the soluble agonist phorbol myristate acetate or
exogenous arachidonic acid led to the production of cyclooxygenase metabolites but not …