Inner ring deiodination of thyroxine and 3, 5, 3′-triiodothyronine by human fetal membranes
E Roti, SL Fang, K Green, LE Braverman… - American journal of …, 1983 - Elsevier
Indirect evidence, based on injection of thyroxine (T 4) into the amniotic cavity of humans,
and maternal thyroidectomy in the rat, suggests that fetal membranes might be capable of
converting T 4 to 3, 3′, 5′-triiodothyronine (rT 3) by virtue of inner ring iodothyronine
deiodinase activity. The present study was undertaken to provide direct evidence that
human fetal membranes contain inner ring iodothyronine deiodinase activity directed toward
T 4 and 3, 5, 3′-triiodothyronine (T 3). Homogenates of human fetal membranes were …
and maternal thyroidectomy in the rat, suggests that fetal membranes might be capable of
converting T 4 to 3, 3′, 5′-triiodothyronine (rT 3) by virtue of inner ring iodothyronine
deiodinase activity. The present study was undertaken to provide direct evidence that
human fetal membranes contain inner ring iodothyronine deiodinase activity directed toward
T 4 and 3, 5, 3′-triiodothyronine (T 3). Homogenates of human fetal membranes were …