[HTML][HTML] Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters
A Garcia, S Cereghini, E Sontag - Journal of Biological Chemistry, 2000 - ASBMB
The transcription factor Sp1 regulates the activity of a large number of eukaryotic gene
promoters, including early SV40 and human immunodeficiency virus type 1 (HIV-1). Here,
we report that expression of SV40 small tumor antigen (small t) in quiescent CV-1 cells
transactivates two Sp1-responsive promoters, including a deletion mutant of HIV-1 LTR,
through specific inhibition of endogenous AC and ABαC forms of protein phosphatase 2A
(PP2A). Expression of a small t mutant, lacking the PP2A-binding domain, failed to …
promoters, including early SV40 and human immunodeficiency virus type 1 (HIV-1). Here,
we report that expression of SV40 small tumor antigen (small t) in quiescent CV-1 cells
transactivates two Sp1-responsive promoters, including a deletion mutant of HIV-1 LTR,
through specific inhibition of endogenous AC and ABαC forms of protein phosphatase 2A
(PP2A). Expression of a small t mutant, lacking the PP2A-binding domain, failed to …