11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

M Bostanjoglo, WB Reeves, RF Reilly… - Journal of the …, 1998 - journals.lww.com
Mineralocorticoid hormones regulate salt transport along the distal nephron by binding to
intracellular receptors and activating gene transcription. Previous experiments showed that
systemic aldosterone infusions stimulate thiazide-sensitive Na and Cl transport by distal
convoluted tubule (DCT) cells; this effect could have been direct or secondary to systemic
hormonal effects. Aldosterone target tissues express both mineralocorticoid receptors and
the metabolic enzyme 11beta-hydroxysteroid dehydrogenase type 2. Mineralocorticoid …