[HTML][HTML] Molecular and functional identification of a Ca2+ (polyvalent cation)-sensing receptor in rat pancreas
JIE Bruce, X Yang, CJ Ferguson, AC Elliott… - Journal of Biological …, 1999 - ASBMB
The balance between the concentrations of free ionized Ca 2+ and bicarbonate in
pancreatic juice is of critical importance in preventing the formation of calcium carbonate
stones. How the pancreas regulates the ionic composition and the level of Ca 2+ saturation
in an alkaline environment such as the pancreatic juice is not known. Because of the tight
cause-effect relationship between Ca 2+ concentration and lithogenicity, and because
hypercalcemia is proposed as an etiologic factor for several pancreatic diseases, we have …
pancreatic juice is of critical importance in preventing the formation of calcium carbonate
stones. How the pancreas regulates the ionic composition and the level of Ca 2+ saturation
in an alkaline environment such as the pancreatic juice is not known. Because of the tight
cause-effect relationship between Ca 2+ concentration and lithogenicity, and because
hypercalcemia is proposed as an etiologic factor for several pancreatic diseases, we have …