[HTML][HTML] Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure
K Haghighi, AG Schmidt, BD Hoit, AG Brittsan… - Journal of Biological …, 2001 - ASBMB
To determine whether selective impairment of cardiac sarcoplasmic reticulum (SR) Ca 2+
transport may drive the progressive functional deterioration leading to heart failure,
transgenic mice, overexpressing a phospholamban Val 49→ Gly mutant (2-fold), which is a
superinhibitor of SR Ca 2+-ATPase affinity for Ca 2+, were generated, and their cardiac
phenotype was examined longitudinally. At 3 months of age, the increased EC 50 level of
SR Ca 2+ uptake for Ca 2+(0.67±0.09 μm) resulted in significantly higher depression of …
transport may drive the progressive functional deterioration leading to heart failure,
transgenic mice, overexpressing a phospholamban Val 49→ Gly mutant (2-fold), which is a
superinhibitor of SR Ca 2+-ATPase affinity for Ca 2+, were generated, and their cardiac
phenotype was examined longitudinally. At 3 months of age, the increased EC 50 level of
SR Ca 2+ uptake for Ca 2+(0.67±0.09 μm) resulted in significantly higher depression of …