[HTML][HTML] Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
KS Hewitson, LA McNeill, MV Riordan, YM Tian… - Journal of Biological …, 2002 - ASBMB
Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent
hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by
2-oxoglutarate (2-OG)-dependent oxygenases mediates ubiquitinylation and proteasomal
destruction of HIF-α. Hydroxylation of an asparagine residue in the C-terminal
transactivation domain (CAD) of HIF-α abrogates interaction with p300, preventing
transcriptional activation. Yeast two-hybrid assays recently identified factor inhibiting HIF …
hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by
2-oxoglutarate (2-OG)-dependent oxygenases mediates ubiquitinylation and proteasomal
destruction of HIF-α. Hydroxylation of an asparagine residue in the C-terminal
transactivation domain (CAD) of HIF-α abrogates interaction with p300, preventing
transcriptional activation. Yeast two-hybrid assays recently identified factor inhibiting HIF …