CO2/HCO3−-responsive soluble adenylyl cyclase as a putative metabolic sensor
JH Zippin, LR Levin, J Buck - Trends in Endocrinology & Metabolism, 2001 - cell.com
JH Zippin, LR Levin, J Buck
Trends in Endocrinology & Metabolism, 2001•cell.comCyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we
identified a novel mammalian source of cAMP–soluble adenylyl cyclase (sAC)–that is
regulated directly by bicarbonate ions (HCO 3−). As the concentration of HCO 3− reflects
cellular levels of carbon dioxide (CO 2), energy-generating metabolic processes (which
increase intracellular CO 2) are poised to activate bicarbonate-responsive sAC. This direct
link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved …
identified a novel mammalian source of cAMP–soluble adenylyl cyclase (sAC)–that is
regulated directly by bicarbonate ions (HCO 3−). As the concentration of HCO 3− reflects
cellular levels of carbon dioxide (CO 2), energy-generating metabolic processes (which
increase intracellular CO 2) are poised to activate bicarbonate-responsive sAC. This direct
link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved …
Abstract
Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP – soluble adenylyl cyclase (sAC) – that is regulated directly by bicarbonate ions (HCO3−). As the concentration of HCO3− reflects cellular levels of carbon dioxide (CO2), energy-generating metabolic processes (which increase intracellular CO2) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.
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