Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra
A Barbin - Mutation Research/Reviews in Mutation Research, 2000 - Elsevier
During the past 25 years, ethenobases have emerged as a new class of DNA lesions with
promutagenic potential. Ethenobases were first investigated as DNA reaction products of
vinyl chloride, an occupational carcinogen causing angiosarcoma of the liver (ASL). They
were subsequently shown to be formed by several carcinogenic agents, including urethane
(ethyl carbamate), and more recently, to occur in various tissues of unexposed humans and
rodents. The endogenous source of ethenobases in DNA is thought to be a lipid …
promutagenic potential. Ethenobases were first investigated as DNA reaction products of
vinyl chloride, an occupational carcinogen causing angiosarcoma of the liver (ASL). They
were subsequently shown to be formed by several carcinogenic agents, including urethane
(ethyl carbamate), and more recently, to occur in various tissues of unexposed humans and
rodents. The endogenous source of ethenobases in DNA is thought to be a lipid …