Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells
A Gentil, F Le Page, J Cadet, A Sarasin - Mutation Research/Fundamental …, 2000 - Elsevier
Ionizing radiations often induce multiple and clustered DNA lesions at the site of DNA
interaction. As a model, we have studied the toxicity and the mutagenicity of two adjacent
oxidative bases as clustered DNA lesions in mammalian cells using shuttle vectors. The
chosen oxidative lesions were 8-oxo-7, 8-dihydroguanine, the formylamine residue resulting
from the oxidation of a pyrimidine base and the tandem lesion 8-oxo-7, 8-dihydroguanine/
formylamine where both modifications are located at a vicinal position. A single-stranded …
interaction. As a model, we have studied the toxicity and the mutagenicity of two adjacent
oxidative bases as clustered DNA lesions in mammalian cells using shuttle vectors. The
chosen oxidative lesions were 8-oxo-7, 8-dihydroguanine, the formylamine residue resulting
from the oxidation of a pyrimidine base and the tandem lesion 8-oxo-7, 8-dihydroguanine/
formylamine where both modifications are located at a vicinal position. A single-stranded …