Hydroxyl radicals and DNA base damage
J Cadet, T Delatour, T Douki, D Gasparutto… - Mutation Research …, 1999 - Elsevier
Modified purine and pyrimidine bases constitute one of the major classes of hydroxyl-radical-
mediated DNA damage together with oligonucleotide strand breaks, DNA-protein cross-links
and abasic sites. A comprehensive survey of the main available data on both structural and
mechanistic aspects of⋅ OH-induced decomposition pathways of both purine and
pyrimidine bases of isolated DNA and model compounds is presented. In this respect,
detailed information is provided on both thymine and guanine whereas data are not as …
mediated DNA damage together with oligonucleotide strand breaks, DNA-protein cross-links
and abasic sites. A comprehensive survey of the main available data on both structural and
mechanistic aspects of⋅ OH-induced decomposition pathways of both purine and
pyrimidine bases of isolated DNA and model compounds is presented. In this respect,
detailed information is provided on both thymine and guanine whereas data are not as …