Extracellular ATP: a growth factor for vascular smooth muscle cells
D Erlinge - General Pharmacology: The Vascular System, 1998 - Elsevier
Extracellular adenosine triphosphate (ATP) is mitogenic for vascular smooth muscle cells
(VSMC) and stimulates several events that are important for cell proliferation: DNA
synthesis, protein synthesis, increase of cell number, immediate early genes, cell-cycle
progression, and tyrosine phosphorylation. 2. Receptor characterization indicates mitogenic
effects of both P2U and P2Y receptors. The P2X receptor is lost in cultured VSMC and is not
involved. Several related biological substances such as UTP, ITP, GTP, AP 4 A, ADP, and …
(VSMC) and stimulates several events that are important for cell proliferation: DNA
synthesis, protein synthesis, increase of cell number, immediate early genes, cell-cycle
progression, and tyrosine phosphorylation. 2. Receptor characterization indicates mitogenic
effects of both P2U and P2Y receptors. The P2X receptor is lost in cultured VSMC and is not
involved. Several related biological substances such as UTP, ITP, GTP, AP 4 A, ADP, and …