In vitro characterization of five humanized OKT3 effector function variant antibodies
D Xu, ML Alegre, SS Varga, AL Rothermel… - Cellular …, 2000 - Elsevier
Orthoclone OKT 3 (mOKT3) is a highly effective agent for the reversal of steroid-resistant
renal allograft rejection. However, its wider use has been limited by the development of a
human anti-mouse antibody response (HAMA) and by the “cytokine release
syndrome”(CRS). CRS has been associated with T cell/monocyte activation and,
secondarily, with activation of the complement cascade. These processes are mediated
through Abs' Fc regions by their abilities to cross-link T cells and mononuclear cells and to …
renal allograft rejection. However, its wider use has been limited by the development of a
human anti-mouse antibody response (HAMA) and by the “cytokine release
syndrome”(CRS). CRS has been associated with T cell/monocyte activation and,
secondarily, with activation of the complement cascade. These processes are mediated
through Abs' Fc regions by their abilities to cross-link T cells and mononuclear cells and to …