Large variations in human foam cell formation in individuals: a fully autologous in vitro assay based on the quantitative analysis of cellular neutral lipids

R Asmis, J Jelk - Atherosclerosis, 2000 - Elsevier
The transformation of monocyte-derived macrophages into lipid-laden foam cells constitutes
a characteristic and crucial event in the development of the earliest atherosclerotic lesions.
We investigated whether the propensity to form foam cells varies among individuals. We
developed a fully autologous foam cell assay based on a recently developed novel culture
technique for human monocyte-derived macrophages (Wintergerst ES, Jelk J, Asmis, R.
Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived …