[HTML][HTML] Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-γ
J Feng, J Han, SFA Pearce, RL Silverstein… - Journal of lipid …, 2000 - ASBMB
CD36, a class B scavenger receptor, is a macrophage receptor for oxidized low density
lipoprotein (OxLDL) and may play a critical role in atherosclerotic foam cell formation. We
have previously demonstrated that OxLDL, macrophage-colony stimulating factor (M-CSF),
and interleukin-4 (IL-4) enhanced expression of CD36. The effect of OxLDL on CD36 is due,
in part, to its ability to activate the transcription factor, PPAR-γ (peroxisome proliferator
activated receptor-γ). Other PPAR-γ ligands (15-deoxyΔ 12, 14 prostaglandin J 2 (15d-PGJ …
lipoprotein (OxLDL) and may play a critical role in atherosclerotic foam cell formation. We
have previously demonstrated that OxLDL, macrophage-colony stimulating factor (M-CSF),
and interleukin-4 (IL-4) enhanced expression of CD36. The effect of OxLDL on CD36 is due,
in part, to its ability to activate the transcription factor, PPAR-γ (peroxisome proliferator
activated receptor-γ). Other PPAR-γ ligands (15-deoxyΔ 12, 14 prostaglandin J 2 (15d-PGJ …