[HTML][HTML] CD86 (B7-2) on human B cells: a functional role in proliferation and selective differentiation into IgE-and IgG4-producing cells
P Jeannin, Y Delneste, S Lecoanet-Henchoz… - Journal of Biological …, 1997 - ASBMB
Immunoglobulin (Ig) E production by B cells requires two primary signals provided by T cells,
interleukin (IL)-4 or IL-13 and CD40 ligand (CD40L). In addition, costimulatory signals, such
as CD23-CD21 interaction, contribute further ensuring a selective control over this
production. Recently, CD28, expressed on T cells, has been reported to be involved in this
process. The CD28 ligands, CD80 (B7-1) and CD86 (B7-2), are expressed on human
tonsillar B cells, and their expression is up-regulated by IL-4, IL-13, and/or an anti-CD40 …
interleukin (IL)-4 or IL-13 and CD40 ligand (CD40L). In addition, costimulatory signals, such
as CD23-CD21 interaction, contribute further ensuring a selective control over this
production. Recently, CD28, expressed on T cells, has been reported to be involved in this
process. The CD28 ligands, CD80 (B7-1) and CD86 (B7-2), are expressed on human
tonsillar B cells, and their expression is up-regulated by IL-4, IL-13, and/or an anti-CD40 …