[HTML][HTML] Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar …
S Qin, K Kawano, C Bruce, M Lin, C Bisgaier… - Journal of lipid …, 2000 - ASBMB
Phospholipid transfer protein gene knock-out (Pltp KO) mice have defective transfer of very
low density lipoprotein (VLDL) phospholipids into high density lipoprotein (HDL) and
markedly decreased HDL levels (Jiang et al. 1999. J. Clin. Invest. 103: 907–914). These
animals also accumulated VLDL-and LDL-sized lipoproteins on a high saturated fat diet.
The goals of this study were to further characterize the abnormal lipoproteins of Pltp KO mice
and to determine the mechanisms responsible for low HDL levels. A lipoprotein fraction …
low density lipoprotein (VLDL) phospholipids into high density lipoprotein (HDL) and
markedly decreased HDL levels (Jiang et al. 1999. J. Clin. Invest. 103: 907–914). These
animals also accumulated VLDL-and LDL-sized lipoproteins on a high saturated fat diet.
The goals of this study were to further characterize the abnormal lipoproteins of Pltp KO mice
and to determine the mechanisms responsible for low HDL levels. A lipoprotein fraction …