The inheritance of high density lipoprotein cholesterol and apolipoproteins AI and A-II
SJ HasstedT, JJ Albers, MC Cheung, LB Jorde… - Atherosclerosis, 1984 - Elsevier
A large pedigree was ascertained through cases of early myocardial infarction. High density
lipoprotein cholesterol and apolipoproteins AI and A-II were measured on family members.
Likelihood analysis, using the polygenic/major gene mixed model, provided no evidence
that major loci play a role in determining the levels of any of the three measurements.
Heritability estimates, assuming polygenic inheritance, were 0.59 and 0.26 for HDL-C level
and A-II level, respectively. No evidence of genetic transmission of AI level was found.
lipoprotein cholesterol and apolipoproteins AI and A-II were measured on family members.
Likelihood analysis, using the polygenic/major gene mixed model, provided no evidence
that major loci play a role in determining the levels of any of the three measurements.
Heritability estimates, assuming polygenic inheritance, were 0.59 and 0.26 for HDL-C level
and A-II level, respectively. No evidence of genetic transmission of AI level was found.