[HTML][HTML] Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice
H Mezdour, R Jones, C Dengremont, G Castro… - Journal of Biological …, 1997 - ASBMB
The effect of hepatic lipase (HL) deficiency on the susceptibility to atherosclerosis was tested
using mice with combined deficiencies in HL and apoE. Mice lacking both HL and apoE
(hhee) have a plasma total cholesterol of 917±252 mg/dl (n= 24), which is 184% that of mice
lacking only apoE (HHee; 497±161 mg/dl, n= 20, p< 0.001). The increase in cholesterol was
mainly in β-migrating very low density lipoproteins, although high density lipoprotein
cholesterol (HDLc) was also increased (53±37 versus 20±13 mg/dl, p< 0.01). Despite the …
using mice with combined deficiencies in HL and apoE. Mice lacking both HL and apoE
(hhee) have a plasma total cholesterol of 917±252 mg/dl (n= 24), which is 184% that of mice
lacking only apoE (HHee; 497±161 mg/dl, n= 20, p< 0.001). The increase in cholesterol was
mainly in β-migrating very low density lipoproteins, although high density lipoprotein
cholesterol (HDLc) was also increased (53±37 versus 20±13 mg/dl, p< 0.01). Despite the …