Mouse models of abnormal skeletal development and homeostasis
W McLean, BR Olsen - TRENDS in Genetics, 2001 - cell.com
W McLean, BR Olsen
TRENDS in Genetics, 2001•cell.comStudies of a number of mouse mutations with skeletal defects have contributed significantly
to the understanding of bone development and homeostasis. In many cases, such mutants
are also genetic models of disorders in humans, characterized by reduced bone mass
(osteoporosis), increased bone mass (osteopetrosis), or abnormalities in endochondral
ossification (chondrodysplasias).
to the understanding of bone development and homeostasis. In many cases, such mutants
are also genetic models of disorders in humans, characterized by reduced bone mass
(osteoporosis), increased bone mass (osteopetrosis), or abnormalities in endochondral
ossification (chondrodysplasias).
Abstract
Studies of a number of mouse mutations with skeletal defects have contributed significantly to the understanding of bone development and homeostasis. In many cases, such mutants are also genetic models of disorders in humans, characterized by reduced bone mass (osteoporosis), increased bone mass (osteopetrosis), or abnormalities in endochondral ossification (chondrodysplasias).
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