Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease
J Ojaimi, CL Masters, C McLean… - Annals of Neurology …, 1999 - Wiley Online Library
J Ojaimi, CL Masters, C McLean, K Opeskin, P McKelvie, E Byrne
Annals of Neurology: Official Journal of the American Neurological …, 1999•Wiley Online LibraryThis study aims to investigate the cellular distribution of human cytochrome c oxidase (COX)
subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains.
The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age‐
matched controls relative to young controls and in the Alzheimer's disease group relative to
both age‐matched and young controls. Results suggest that these age‐associated changes
are more marked in Alzheimer's disease.
subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains.
The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age‐
matched controls relative to young controls and in the Alzheimer's disease group relative to
both age‐matched and young controls. Results suggest that these age‐associated changes
are more marked in Alzheimer's disease.
Abstract
This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age‐matched controls relative to young controls and in the Alzheimer's disease group relative to both age‐matched and young controls. Results suggest that these age‐associated changes are more marked in Alzheimer's disease.
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