[HTML][HTML] Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
CL Wellington, LM Ellerby, AS Hackam… - Journal of Biological …, 1998 - ASBMB
The neurodegenerative diseases Huntington disease, dentatorubropallidoluysian atrophy,
spinocerebellar atrophy type 3, and spinal bulbar muscular atrophy are caused by
expansion of a polyglutamine tract within their respective gene products. There is increasing
evidence that generation of truncated proteins containing an expanded polyglutamine tract
may be a key step in the pathogenesis of these disorders. We now report that, similar to
huntingtin, atrophin-1, ataxin-3, and the androgen receptor are cleaved in apoptotic extracts …
spinocerebellar atrophy type 3, and spinal bulbar muscular atrophy are caused by
expansion of a polyglutamine tract within their respective gene products. There is increasing
evidence that generation of truncated proteins containing an expanded polyglutamine tract
may be a key step in the pathogenesis of these disorders. We now report that, similar to
huntingtin, atrophin-1, ataxin-3, and the androgen receptor are cleaved in apoptotic extracts …