[HTML][HTML] Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95
Y Sun, A Savanenin, PH Reddy, YF Liu - Journal of Biological Chemistry, 2001 - ASBMB
Increased glutamate-mediated excitotoxicity seems to play an important role in the
pathogenesis of Huntington's disease (Tabrizi, SJ, Cleeter, MW, Xuereb, J., Taaman, JW,
Cooper, JM, and Schapira, AH (1999) Ann. Neurol. 45, 25–32). However, how
polyglutamine expansion in huntingtin promotes glutamate-mediated excitotoxicity remains
a mystery. In this study we provide evidence that (i) normal huntingtin is associated withN-
methyl-d-aspartate (NMDA) and kainate receptors via postsynaptic density 95 (PSD-95),(ii) …
pathogenesis of Huntington's disease (Tabrizi, SJ, Cleeter, MW, Xuereb, J., Taaman, JW,
Cooper, JM, and Schapira, AH (1999) Ann. Neurol. 45, 25–32). However, how
polyglutamine expansion in huntingtin promotes glutamate-mediated excitotoxicity remains
a mystery. In this study we provide evidence that (i) normal huntingtin is associated withN-
methyl-d-aspartate (NMDA) and kainate receptors via postsynaptic density 95 (PSD-95),(ii) …