Publisher Summary Deoxyribonucleic acid (DNA) methylation, a covalent modification of the
genome, is emerging as an important player in the regulation of gene expression. This
chapter discusses the different components of the DNA methylation machinery responsible
for replicating the DNA methylation pattern. A number of DNA methyltransferases (DNMT)
have been identified and a demethylase has recently been reported. Because the DNA
methylation pattern is critical for gene expression programs, the cell possesses a number of …