Peroxisome proliferator-activated receptor-γ (PPAR-γ), a member of the nuclear hormone
receptor superfamily, plays a critical role in adipocyte differentiation and glucose
homeostasis. It has been implicated that PPAR-γ functions as a regulator of cellular
proliferation and inflammatory responses. In the present study, we examined whether
troglitazone, a selective PPAR-γ agonists, ameliorated experimental autoimmune
encephalomyelitis (EAE) induced by administration of myelin oligodendrocyte glycoprotein …