[HTML][HTML] Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
B Antonsson, S Montessuit, B Sanchez… - Journal of Biological …, 2001 - ASBMB
Bax is a Bcl-2 family protein with proapoptotic activity, which has been shown to trigger
cytochrome crelease from mitochondria both in vitro and in vivo. In control HeLa cells, Bax is
present in the cytosol and weakly associated with mitochondria as a monomer with an
apparent molecular mass of 20,000 Da. After treatment of the HeLa cells with the apoptosis
inducer staurosporine or UV irradiation, Bax associated with mitochondria is present as two
large molecular weight oligomers/complexes of 96,000 and 260,000 Da, which are …
cytochrome crelease from mitochondria both in vitro and in vivo. In control HeLa cells, Bax is
present in the cytosol and weakly associated with mitochondria as a monomer with an
apparent molecular mass of 20,000 Da. After treatment of the HeLa cells with the apoptosis
inducer staurosporine or UV irradiation, Bax associated with mitochondria is present as two
large molecular weight oligomers/complexes of 96,000 and 260,000 Da, which are …