[HTML][HTML] Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-α-induced liver injury
Y Zhao, S Li, EE Childs, DK Kuharsky… - Journal of Biological …, 2001 - ASBMB
Tumor necrosis factor-α (TNFα)-induced cytotoxicity contributes to the pathogenesis in
inflammatory and immune responses. Here, we studied the role of pro-death Bcl-2 family
proteins and the mitochondria apoptosis pathway in the development of TNFα-induced
hepatic injury during endotoxemia. After treating mice with lipopolysaccharide or TNFα in the
presence ofd-galactosamine, Bid was cleaved and translocated to mitochondria in
hepatocytes. Independently, Bax was also activated by the death receptor engagement and …
inflammatory and immune responses. Here, we studied the role of pro-death Bcl-2 family
proteins and the mitochondria apoptosis pathway in the development of TNFα-induced
hepatic injury during endotoxemia. After treating mice with lipopolysaccharide or TNFα in the
presence ofd-galactosamine, Bid was cleaved and translocated to mitochondria in
hepatocytes. Independently, Bax was also activated by the death receptor engagement and …