[HTML][HTML] Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in …
Y Lavie, H Cao, A Volner, A Lucci, TY Han… - Journal of Biological …, 1997 - ASBMB
We have previously shown that multidrug-resistant cancer cells display elevated levels of
glucosylceramide (Lavie, Y., Cao, H., Bursten, SL, Giuliano, AE, and Cabot, MC (1996) J.
Biol. Chem. 271, 19530-19536). In this study we used the multidrug-resistant human breast
cancer cell line MCF-7-Adriamycin-resistant (AdrR), which exhibits marked accumulation of
glucosylceramide compared with the parental MCF-7 wild type (drug-sensitive) cell line, to
define the relationship between glycolipids and multidrug resistance (MDR). Herein it is …
glucosylceramide (Lavie, Y., Cao, H., Bursten, SL, Giuliano, AE, and Cabot, MC (1996) J.
Biol. Chem. 271, 19530-19536). In this study we used the multidrug-resistant human breast
cancer cell line MCF-7-Adriamycin-resistant (AdrR), which exhibits marked accumulation of
glucosylceramide compared with the parental MCF-7 wild type (drug-sensitive) cell line, to
define the relationship between glycolipids and multidrug resistance (MDR). Herein it is …