[HTML][HTML] Accumulation of glucosylceramides in multidrug-resistant cancer cells
Y Lavie, H Cao, SL Bursten, AE Giuliano… - Journal of Biological …, 1996 - ASBMB
Multidrug-resistant (MDR) tumors and cancer cell lines demonstrate a wide variety of
biochemical changes. In this study we used drug-sensitive wild-type (wt) cancer cell lines
and respective MDR subclones, and we demonstrate the accumulation of distinct lipids in
MDR cells. These lipids were either absent or present at very low levels in drug-sensitive
cells. The compounds, termed lipid-1 and lipid-2, migrated on thin-layer chromatography as
a doublet. They could be radiolabeled by incubating MCF-7-AdrR (Adriamycin-resistant) …
biochemical changes. In this study we used drug-sensitive wild-type (wt) cancer cell lines
and respective MDR subclones, and we demonstrate the accumulation of distinct lipids in
MDR cells. These lipids were either absent or present at very low levels in drug-sensitive
cells. The compounds, termed lipid-1 and lipid-2, migrated on thin-layer chromatography as
a doublet. They could be radiolabeled by incubating MCF-7-AdrR (Adriamycin-resistant) …