[HTML][HTML] Compartmentalized production of ceramide at the cell surface
P Liu, RGW Anderson - Journal of Biological Chemistry, 1995 - ASBMB
Ceramide produced by the hydrolysis of sphingomyelin is an important cellular intermediate
in hormone action. Here, we present evidence that interleukin 1β (IL-1β) binding to normal
human fibroblasts initiates a lipid messenger cascade that takes place in a sphingomyelin-
rich plasma membrane domain with the characteristics of caveolae. Hormone binding first
stimulated the appearance of diacylglycerol (DAG) in a caveolea-rich membrane fraction
isolated from whole cells. This was immediately followed by the loss of a resident population …
in hormone action. Here, we present evidence that interleukin 1β (IL-1β) binding to normal
human fibroblasts initiates a lipid messenger cascade that takes place in a sphingomyelin-
rich plasma membrane domain with the characteristics of caveolae. Hormone binding first
stimulated the appearance of diacylglycerol (DAG) in a caveolea-rich membrane fraction
isolated from whole cells. This was immediately followed by the loss of a resident population …