[HTML][HTML] Cu (II) potentiation of Alzheimer Aβ neurotoxicity: correlation with cell-free hydrogen peroxide production and metal reduction
Oxidative stress markers as well as high concentrations of copper are found in the vicinity of
Aβ amyloid deposits in Alzheimer's disease. The neurotoxicity of Aβ in cell culture has been
linked to H 2 O 2 generation by an unknown mechanism. We now report that Cu (II)
markedly potentiates the neurotoxicity exhibited by Aβ in cell culture. The potentiation of
toxicity is greatest for Aβ1–42> Aβ1–40≫ mouse/rat Aβ1–40, corresponding to their relative
capacities to reduce Cu (II) to Cu (I), form H 2 O 2 in cell-free assays and to exhibit amyloid …
Aβ amyloid deposits in Alzheimer's disease. The neurotoxicity of Aβ in cell culture has been
linked to H 2 O 2 generation by an unknown mechanism. We now report that Cu (II)
markedly potentiates the neurotoxicity exhibited by Aβ in cell culture. The potentiation of
toxicity is greatest for Aβ1–42> Aβ1–40≫ mouse/rat Aβ1–40, corresponding to their relative
capacities to reduce Cu (II) to Cu (I), form H 2 O 2 in cell-free assays and to exhibit amyloid …