[PDF][PDF] New animal models for Parkinson's disease

TM Dawson - Cell, 2000 - cell.com
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New Insight into PD Pathogenesis though young adults and even children can be affected
The discoveries of genetic linkages for PD provide promby this devastating disease (Lang
and Lozano, 1998). In ise for new insights into the pathogenesis of the disease. the last few
years, significant progress has been made Rare missense mutations in α-synuclein (α-syn),
A53T, into unraveling the causes of PD. In particular, genes and A30P cause autosomal
dominant PD in a large Itallinked to familial PD have been identified yielding fresh ian …
New Insight into PD Pathogenesis though young adults and even children can be affected The discoveries of genetic linkages for PD provide promby this devastating disease (Lang and Lozano, 1998). In ise for new insights into the pathogenesis of the disease. the last few years, significant progress has been made Rare missense mutations in α-synuclein (α-syn), A53T, into unraveling the causes of PD. In particular, genes and A30P cause autosomal dominant PD in a large Itallinked to familial PD have been identified yielding fresh ian, American, Greek kindred and a small German pediavenues of investigation. In other neurodegenerative gree, respectively (Polymeropoulos, 1998). α-syn and disorders animal models of human familial-linked disrelated family members are abundant neuronal cytosolic ease have provided tremendous insight and clues into proteins enriched at presynaptic terminals and are the pathogenesis of these disorders. Until recently, there thought to be involved in synaptic function and plasticity has not been an animal model of hereditary PD. Two (Clayton and George, 1998). A truncated fragment of α-syn recent papers by Masliah and colleagues (Masliah et was also identified as the non-฿-amyloid component of al., 2000) and Feany and Bender (2000) describe such Alzheimer’s disease senile plaques (Ueda et al., 1993). models and provide us with the opportunity to discuss Following the discovery of the α-syn mutations, α-syn recent advances in our understanding of PD pathowas quickly discovered to be a major component of genesis. Lewy bodies and neurites, and it is abundant in pale
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