[HTML][HTML] α7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A β-amyloid-induced neurotoxicity
T Kihara, S Shimohama, H Sawada, K Honda… - Journal of Biological …, 2001 - ASBMB
Multiple lines of evidence, from molecular and cellular to epidemiological, have implicated
nicotinic transmission in the pathogenesis of Alzheimer's disease (AD). Here we show the
signal transduction mechanism involved in nicotinic receptor-mediated protection against β-
amyloid-enhanced glutamate neurotoxicity. Nicotine-induced protection was suppressed by
an α7 nicotinic receptor antagonist (α-bungarotoxin), a phosphatidylinositol 3-kinase (PI3K)
inhibitor (LY294002 and wortmannin), and a Src inhibitor (PP2). Levels of phosphorylated …
nicotinic transmission in the pathogenesis of Alzheimer's disease (AD). Here we show the
signal transduction mechanism involved in nicotinic receptor-mediated protection against β-
amyloid-enhanced glutamate neurotoxicity. Nicotine-induced protection was suppressed by
an α7 nicotinic receptor antagonist (α-bungarotoxin), a phosphatidylinositol 3-kinase (PI3K)
inhibitor (LY294002 and wortmannin), and a Src inhibitor (PP2). Levels of phosphorylated …