[HTML][HTML] Identification and molecular characterization of m3 muscarinic receptor dimers
FY Zeng, J Wess - Journal of Biological Chemistry, 1999 - ASBMB
Several studies suggest, but do not prove directly, that muscarinic receptors may be able to
form dimeric or oligomeric arrays. To address this issue in a more direct fashion, we
designed a series of biochemical experiments using a modified version of the rat m3
muscarinic receptor (referred to as m3′) as a model system. When membrane lysates
prepared from m3′ receptor-expressing COS-7 cells were subjected to Western blot
analysis under non-reducing conditions, several immunoreactive species were observed …
form dimeric or oligomeric arrays. To address this issue in a more direct fashion, we
designed a series of biochemical experiments using a modified version of the rat m3
muscarinic receptor (referred to as m3′) as a model system. When membrane lysates
prepared from m3′ receptor-expressing COS-7 cells were subjected to Western blot
analysis under non-reducing conditions, several immunoreactive species were observed …