[HTML][HTML] Determinants of vascular permeability in the kidney glomerulus
Y Hamano, JA Grunkemeyer, A Sudhakar… - Journal of Biological …, 2002 - ASBMB
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all
kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the
urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the
human mutations in nephrin, podocin, α-actinin-4, COL4A3, and COL4A5 genes expressed
in the glomeruli have been implicated to cause alterations in glomerular filtration apparatus.
Nevertheless, the expression of these proteins in relation to each other in mouse models for …
kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the
urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the
human mutations in nephrin, podocin, α-actinin-4, COL4A3, and COL4A5 genes expressed
in the glomeruli have been implicated to cause alterations in glomerular filtration apparatus.
Nevertheless, the expression of these proteins in relation to each other in mouse models for …