[HTML][HTML] Characterization of Osf1, an Osteoblast-specific Transcription Factor Binding to a Critical cis-acting Element in the MouseOsteocalcin Promoters
T Schinke, G Karsenty - Journal of Biological Chemistry, 1999 - ASBMB
To elucidate the mechanisms of osteoblast-specific gene expression we are studying the
regulation ofosteocalcin, the most osteoblast-specific gene. Previous studies of OG2, one of
the two mouse osteocalcin genes, identified two osteoblast-specific cis-acting elements,
OSE1 and OSE2, the latter being the binding site of Cbfa1, the only osteoblast-specific
transcription factor known to date. Here we show that OSE1 is a cis-acting element as
important as OSE2 for the osteoblast-specific expression of OG2 in cell culture and …
regulation ofosteocalcin, the most osteoblast-specific gene. Previous studies of OG2, one of
the two mouse osteocalcin genes, identified two osteoblast-specific cis-acting elements,
OSE1 and OSE2, the latter being the binding site of Cbfa1, the only osteoblast-specific
transcription factor known to date. Here we show that OSE1 is a cis-acting element as
important as OSE2 for the osteoblast-specific expression of OG2 in cell culture and …