Evolving concepts in the pathogenesis of chronic obstructive pulmonary disease
SD Shapiro - Clinics in chest medicine, 2000 - chestmed.theclinics.com
From the time of Laennec through the first half of the twentieth century, mechanical
explanations for chronic obstructive pulmonary disease (COPD) dominated, and the
importance of cigarette smoking was not fully appreciated. As early as 1905, however, Opie
suggested that enzymes and antienzymes determined the risk of ernphy~ ema.~~ In the late
1950s, Liebowz9 proposed the vascular atrophy model for emphysema, which garnered
little attention once the pr0teinase: antiproteinase hypothesis evolved in the early 1960s …
explanations for chronic obstructive pulmonary disease (COPD) dominated, and the
importance of cigarette smoking was not fully appreciated. As early as 1905, however, Opie
suggested that enzymes and antienzymes determined the risk of ernphy~ ema.~~ In the late
1950s, Liebowz9 proposed the vascular atrophy model for emphysema, which garnered
little attention once the pr0teinase: antiproteinase hypothesis evolved in the early 1960s …