Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1–associated cytokines
J Napoli, GA Bishop, PH McGuinness, DM Painter… - Hepatology, 1996 - journals.lww.com
An imbalance between T helper cell (Th) 1 and Th2–like cytokines has been described in
several chronic infectious diseases. We therefore analyzed the intrahepatic messenger RNA
(mRNA) expression of Th1–like (interleukin [IL]–2, interferon [IFN]–gamma) and Th2–like (IL–
4, IL–10) cytokines in chronic hepatitis C patients (n= 17) and controls (n= 6) and correlated
the results with liver histology and intrahepatic viral load. Intrahepatic cytokine mRNA and
hepatitis C virus (HCV) RNA were quantitatively assessed by polymerase chain reaction …
several chronic infectious diseases. We therefore analyzed the intrahepatic messenger RNA
(mRNA) expression of Th1–like (interleukin [IL]–2, interferon [IFN]–gamma) and Th2–like (IL–
4, IL–10) cytokines in chronic hepatitis C patients (n= 17) and controls (n= 6) and correlated
the results with liver histology and intrahepatic viral load. Intrahepatic cytokine mRNA and
hepatitis C virus (HCV) RNA were quantitatively assessed by polymerase chain reaction …