Role of Jak kinases and STATs in cytokine signal transduction
WJ Leonard - International journal of hematology, 2001 - Springer
International journal of hematology, 2001•Springer
The Janus family tyrosine kinase—signal transducer and activator of transcription (Jak-
STAT) signaling pathway is broadly used by interferons and type I cytokines. These
cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn
phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are
cytosolic proteins; after ssactivation, however, they are translocated to the nucleus where
they function as transcription factors. This review summarizes salient features of the Jak …
STAT) signaling pathway is broadly used by interferons and type I cytokines. These
cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn
phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are
cytosolic proteins; after ssactivation, however, they are translocated to the nucleus where
they function as transcription factors. This review summarizes salient features of the Jak …
Abstract
The Janus family tyrosine kinase—signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins; after ssactivation, however, they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.
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