Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro
M Hashimoto, LJ Hsu, Y Xia, A Takeda, A Sisk… - …, 1999 - journals.lww.com
The precursor of non-amyloid β protein component of Alzheimer's disease amyloid (NACP/α-
synuclein), found in Lewy bodies of Parkinson's disease (PD), is a presynaptic protein
genetically linked to some familial types PD. Mechanisms of abnormal NACP/α-synuclein
aggregation in neurodegenerative diseases are unclear. Since oxidative stress might play a
role in PD pathogenesis, we investigated the role of iron and peroxide in NACP/α-synuclein
aggregation. Immunoblot analysis showed that human NACP/α-synuclein (but not β …
synuclein), found in Lewy bodies of Parkinson's disease (PD), is a presynaptic protein
genetically linked to some familial types PD. Mechanisms of abnormal NACP/α-synuclein
aggregation in neurodegenerative diseases are unclear. Since oxidative stress might play a
role in PD pathogenesis, we investigated the role of iron and peroxide in NACP/α-synuclein
aggregation. Immunoblot analysis showed that human NACP/α-synuclein (but not β …