[HTML][HTML] The protein kinase/endoribonuclease IRE1α that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain
CY Liu, HN Wong, JA Schauerte… - Journal of Biological …, 2002 - ASBMB
In response to accumulation of unfolded proteins in the endoplasmic reticulum (ER), cells
activate an intracellular signal transduction pathway called the unfolded protein response
(UPR). IRE and PERK are the two type-I ER transmembrane protein kinase receptors that
signal the UPR. The N-terminal luminal domains (NLDs) of IRE1 and PERK sense ER stress
conditions by a common mechanism and transmit the signal to regulate the cytoplasmic
domains of these receptors. To provide an experimental system amenable to detailed …
activate an intracellular signal transduction pathway called the unfolded protein response
(UPR). IRE and PERK are the two type-I ER transmembrane protein kinase receptors that
signal the UPR. The N-terminal luminal domains (NLDs) of IRE1 and PERK sense ER stress
conditions by a common mechanism and transmit the signal to regulate the cytoplasmic
domains of these receptors. To provide an experimental system amenable to detailed …