[HTML][HTML] Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
PM Snyder, DR Olson, BC Thomas - Journal of Biological Chemistry, 2002 - ASBMB
The epithelial Na+ channel (ENaC) forms the pathway for Na+ absorption across epithelia,
including the kidney collecting duct, where it plays a critical role in Na+ homeostasis and
blood pressure control. Na+ absorption is regulated in part by mechanisms that control the
expression of ENaC at the apical cell surface. Nedd4 family members (eg Nedd4, Nedd4-2)
bind to the channel and decrease its surface expression by catalyzing its ubiquitination and
degradation. Conversely, serum and glucocorticoid-regulated kinase (SGK), a downstream …
including the kidney collecting duct, where it plays a critical role in Na+ homeostasis and
blood pressure control. Na+ absorption is regulated in part by mechanisms that control the
expression of ENaC at the apical cell surface. Nedd4 family members (eg Nedd4, Nedd4-2)
bind to the channel and decrease its surface expression by catalyzing its ubiquitination and
degradation. Conversely, serum and glucocorticoid-regulated kinase (SGK), a downstream …