[HTML][HTML] Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine …

M Schwarz, DW Russell, JM Dietschy, SD Turley - Journal of lipid research, 2001 - ASBMB
Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase
(CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase
(CYP27). These studies used mice lacking cholesterol 7α-hydroxylase (Cyp7a1−/−) to
establish whether the loss of the classic pathway affected cholesterol homeostasis differently
in males and females, and to determine if the rate of bile acid synthesis via alternate
pathways was responsive to changes in the enterohepatic flux of cholesterol and bile acids …