[HTML][HTML] Transcriptional regulation of glutaredoxin and thioredoxin pathways and related enzymes in response to oxidative stress
MJ Prieto-Alamo, J Jurado, R Gallardo-Madueno… - Journal of Biological …, 2000 - ASBMB
We examined the in vivo expression of up to 16 genes encoding for components of both
glutaredoxin and thioredoxin systems and for members of the OxyR and SoxRS regulons.
We demonstrated that grxA (Grx1) transcription is triggered in bacteria lacking Trx1 (trxA)
and GSH (gshA) in an OxyR-dependent manner. We also indicated that, unlike OxyR, SoxR
is not constitutively activated in the oxidizing environment of trxA gshA mutants. We
discovered that the lack of Trx1 plus GSH increases the steady-state levels of Trx reductase …
glutaredoxin and thioredoxin systems and for members of the OxyR and SoxRS regulons.
We demonstrated that grxA (Grx1) transcription is triggered in bacteria lacking Trx1 (trxA)
and GSH (gshA) in an OxyR-dependent manner. We also indicated that, unlike OxyR, SoxR
is not constitutively activated in the oxidizing environment of trxA gshA mutants. We
discovered that the lack of Trx1 plus GSH increases the steady-state levels of Trx reductase …